Cosmetic peptide
 

Brand Name or Common Name	Chemical Name
AHK-Cu	AHK-Cu
AHK	AHK
Tripeptide
Melanostatin
Vialox pentapeptide-3	pentapeptide-3V
Leuphasyl
Tripeptide-1(Copper Peptide)	(GHK)2-Cu
Palmitoyl Tripeptide 3
Lipopeptide Acetate
Matrixyl acetate
Argirelin	Acetyl Hexapeptide-3
Palmitoyl Tripeptide	Pal-GHK
Pal-AHK	Pal-AHK
Matrixyl 3000
SNAP-8	Acetyl Octapeptide-8
Serilesine	Hexapeptide-10
Palmitoyl Tetrapeptide-3	Rigin(Pal-GQPR)

  
  
1.AHK-Cu(AHK.Cu Hcl)
AHK-cu stimulated growth of dermal papilla cells. Apoptotic cells were decreased compared with control. The level of caspase-3 and PARP was decreased in AHK-cu treated group than serum-free control. In human hair follicle organ culture, the elongation of hair was increased over 155% in AHK-cu treated group.
STORAGR:
Evades light,cold storage( 2~8 degree centigrade)
 
2.AHK
FUNCTION:
AHK stimulate the growth of dermal papilla cells. Apoptotic cells were decreased compared with control.
SPECIFICATION:
CAS No : 214047-00-4
MF : C15H26N6O4
Form : white powder
Standar: CP2010 USP32 AJI EP
Recommended limit: 3 years
STORAGE:Evades light,cold storage( 2~8 degree centigrade)Packaging & Delivery
   
3.Tripeptide
CAS No:147732-56-7
MF: C14H24N6O4
Form :blue powder
FUNCTIONS:
HUMAN FIBROBLASTS:
Recent studies have revealed many new aspects of molecular actions of the copper-peptide GHK-Cu. Pollard at al established that GHK-Cu is able to restore function of human fibroblasts damaged by radiation treatment thus accelerate the healing and regenerative processes.
NERVE REGENERATION:
In 2005, Ahmed et al. demonstrated that GHK promotes nerve regeneration. Axon regeneration was studied using collagen tubes with incorporated peptides. GHK increased the production of nerve growth factors, expression of integrins and increased the rate of regeneration of myelinated nerve fibers.Â
STEM CELLS:
In 2009, a group of researchers from the Seoul National University (Republic of Korea) demonstrated that the copper-peptide GHK-Cu stimulated proliferation of keratinocytes and increased expression of integrins and p63 protein in the epidermal stem cells. Since p63 is considered to be an important marker of stem cell and anti-senescence protein, the authors concluded that GHK-copper is able to revive the proliferative potential of epidermal stem cells and increase their ability to repair tissue.
ANTI-CANCER EFFECTS:
In 2010, Hong Y. et al. (Department of Colorectal Surgery, Singapore General Hospital, Singapore) demonstrated that GHK-Cu is able to reverse the expression of certain genes involved in metastatic spreading of colon cancer. GHK-Cu was effective at a very low concentration – 1mk
STORAGE:
Evades light,cold storage( 2~8 degree centigrade)
  
4.Melanostatin
Functions:
Melanostatin, a thirty-six amino acid peptide recently isolated from the frog brain due to its ability to inhibit alpha-melanocyte-stimulating hormone (alpha-MSH) release, is the amphibian counterpart of mammalian neuropeptide Y (NPY). The effect of synthetic melanostatin on the bioelectrical activity of cultured frog melanotrophs was studied in 124 cells by using the whole-cell patch-clamp technique.
Solubility
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Specifications
CAS No.: 60731-46-6 Other Names: Elcatonin MF: C148H244N42O47
EINECS No.: 60731-46-6 Place of Origin: Henan China (Mainland) Type: cosmetic peptides
Purity: over 95% Brand Name: new sensation Model Number: 60731-46-6
Application: polypeptide Appearance: powder Product Categories: Amino Acid Derivatives;Peptide
  
5.Vialox PentaPeptide-3
FUNCTION:
Vialox is an anti-wrinkle ingredient that is very potent. It is found in the form of a powder kit and has been proven to reduce wrinkling by 49%. It works by reducing the contraction of muscle cells. It is widely known to be similar to Botox, but is a topical cream, not an injection, making it attractive to those who do not like the idea of injections on their face.
The use of Vialox can exhibit a Botox-like reduction in wrinkles. Used twice a day, for 28 days, volunteers using Vialox in clinical studies applied the substance on half the face. The subjects were women who were between the ages of thirty and sixty. The primary use of Vialox was for the decrease in Crowâ?™s feet wrinkles, but it has now been found to be effect on other facial wrinkle
SPECIFICATION
CAS No.:9087-70-1 Other Names:Pentapeptide-3 MF:C31H52O3
EINECS No.:231-710-0 Place:China (Mainland) Type:Dyestuff Intermediates, Flavor & Fragranc…
Purity:99%
Model Number:usp30
Application:Cosmetics raw materials Appearance:white powder Purity:99%
Characteristics:white powder CAS:7695-91-2 EINECS:231-710-0
Molecular Weight:231.14

6.Leuphasyl
FUNCTIOON:
Leuphasyl reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.
Leuphasyl targets in vitro the wrinkle-formation mechanism of expression wrinkles in a new way, offering an alternative to peptides like Argireline.
Leuphasyl can be incorporated in cosmetic formulations such as emulsions, gels, serums, etc., where removal of the deep lines or wrinkles in the forehead or around the eye area is desired.
Incorporation: Leuphasyl should be processed below 40°C (104°F) at the final stage of the manufacturing process.
SPECFICTION
Appearance: Colorless, translucent solutionSolubility: Water SolublepH (as supplied): 2.0 – 5.0Preservative:Caprylyl Glycol at 0.5.6%
  
7.Tripeptide-1
CAS No :147732-56-7
MF : C14H24N6O4
Functions:
Nerve regeneration
In 2005, Ahmed et al. demonstrated that GHK promotes nerve regeneration. Axon regeneration was studied using collagen tubes with incorporated peptides. GHK increased migration of hematogenous cells into collagen tube, production of nerve growth factors, expression of integrins and the rate of regeneration of myelinated nerve fibers. In addition, GHK also increased axon count and proliferation of Schwann cells compared to the control.
Effect on stem cells
In 2009, a group of researchers from the Seoul National University (Republic of Korea) demonstrated that the copper-peptide GHK-Cu stimulated proliferation of keratinocytes and increased expression of integrins and p63 protein in the epidermal stem cells. Since p63 is considered to be an important marker of stem cell and anti-senescence protein, the authors concluded that GHK-copper is able to revive the proliferative potential of epidermal stem cells and increase their ability to repair tissue.
Anti-cancer effect
In 2010, Hong Y. et al. demonstrated that GHK-Cu is able to reverse the expression of certain genes involved in metastatic spreading of colon cancer. GHK-Cu was effective at a very low concentration – 1mkM. 
Cosmetic use
Facial studies
Copper peptide GHK-Cu is widely used in anti-aging cosmetics (INCI name: Copper tripeptide-1). Several controlled facial studies confirmed anti-aging, firming and anti-wrinkle activity of copper peptide GHK-Cu.
Abdulghani et al. established that facial cream containing GHK-Cu increased collagen in photoaged skin of 20 female volunteers, performing better than vitamin C and retinoic acid.
 
Leyden et al. conducted a 12-week facial study of GHK-Cu containing face and eye cream, reporting significant improvement of skin laxity, clarity and appearance, reduced fine lines and the depths of wrinkles and increased skin density and thickness comparing to placebo. GHK-Cu eye cream performed better than vitamin K cream.
 
Hair growth
Copper peptide GHK-Cu and its analogues were found to stimulate hair growth. In some circumstances, the efficiency of synthetic analog of GHK-Cu was similar to that of 5% minoxidil. A commercial product GraftCyte was clinically proven to improve hair transplantation outcome.
 
 8.Palmitoyl Tripeptide
Molecular Formula: C30H54N6O5
Purity Level: >98%
Molecular Weight: 578.8
CAS NO: 147732-56-7
Functions:
Pal-GHK acts as messengers of cutaneous restructuration and repair,this peptide works synergistically to restore and maintain the skin’s youthful appearance.Pal-GHK is useful in anti-aging products and wrinkle treatment products such as gels,serums,lotions and creams.
  
9.Lipopeptide Acetate
Functions:
Lipopeptides, have been shown in scientific studies, to boost cell’s natural productivity levels and are considered to be one of nature’s most powerful anti-agers by interacting with cell membranesto
boost and revitalize the natural function of the cells, renewing them to maximum growth potential. Unlike water-soluble peptides, lipopeptides are highly biocompatible with skin’s natural structure.
  
10.Matrixyl Acetate
CAS NO:53886
Molecular Formula: C39H75N7O10
Molecular Weight: 802.05
Sequence (Three-Letter Code): Pal-Lys-Thr-Thr-Ser-OH or Pal-KTTS-OH
What is Matrixyl?
Active Substance: Matrixyl is a lipopeptide, a fatty acid mixed with amino acids.
It is also considered to be a synthetic isomer (an isomer is a molecule that has an identical structure
to another molecule but different atomic components). The active element in Matrixyl is called Micro-collagen – another peptide.
Functions:
Matrixyl stimulates the lower layers of the skin to heal themselves, thus accelerating the healing of wounds.
Cells called fibroblasts are responsible for knitting together wounds of the skin. As you may know, as one ages
wounds take longer to heal. This is partially because fibroblasts slowly lose the capacity for collagen production.
- Increase overall collagen synthesis by up to 117%
- Increase collagen IV synthesis by up to 327%
- Increase hyaluronic acid synthesis by up to 267%
Deep wrinkles were reduced by half. Smaller wrinkles and fine lines
Specifications:
1 .Appearance :White powder
2 .Water Content(Karl Fischer) :≤5.0%
3 .Acetate Content(by HPLC) :≤15.0%
4 .Amino Acid Composition :±10% of theoretical
5 .Purity (by HPLC) :≥95.0%
6 .Single Impurity(by HPLC) :≤2.0%
7 .Peptide Content(by %N ) :≥80%
8 .Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
9 .Bacterial Endotoxins :≤10EU/mg
Storage:Evades light,cold storage( 2~8 degree centigrade
   
11.Argirelin(Acetyl Hexapeptide-3)
CAS NO.:616204-22-9
Molecular formula:C34H60N14O12S
Sequence:Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Purity:Min.99%(by HPLC)
Functions:
1.Argirelin reduces existing facial wrinkles.
2.Argirelin is effective against the development of new wrinkles.
3.Argirelin decreases the depth of facial wrinkles caused by the contraction of muscles from facial expressions, especially near the eyes and on the forehead.
Specifications:
1. Appearance: white powder
2. Appearance of solution: clarify solution
3. Colour of solution: colorless
4. Water content(Karl Fischer): NMT 6%
5. Acetate content(by HPLC): NMT 15%
6. Purity(by HPLC): NLT 99%
7. Total impurities: NMT 1.0%
8 .Single impurity(by HPLC): NMT 1.0%
9. Peptide content(by %N): NLT 80%
  
12.Name: Palmitoyl Tripeptide
 Chemical Name: Pal-GHK
 Molecular Formula: C30H54N6O5
Purity Level: >98%                  
Molecular Weight: 578.8
Cas Registry No: 147732-56-7
This is a highly bio-active, deeply skin penetrating peptide that is able to activate the tissue growth factor that stimulates collagen synthesis in the skin. Simply put, this peptide helps to strengthen skin and reduce the appearance of fine lines and wrinkles. This peptide complex minimizes eye puffiness and fluid retention under the eye. It also controls inflammation and improves firming and elasticity of the skin. 
Pal-GHK acts as messengers of cutaneous restructuration and repair,this peptide works synergistically to restore and maintain the skin's youthful appearance.Pal-GHK is useful in anti-aging products and wrinkle treatment products such as gels,serums,lotions and creams.
   
13.Pal-AHK
cosmetic peptide Pal-AHK (Pal-Ala-His-Lys)
Purity:98%
Series:Pal-Ala-His-Lys
 
 14.Matrixyl 3000
Matrixyl 3000 as a synergistic combination
Matrixyl 3000 combines palmitoyl oligopeptide and palmitoyl tetrapeptide-7 not just because two active ingredients are better then one. According to the Sederma corporation, these two peptides produce a synergy when used together, i.e. the skin benefits of such combination are greater than what one would expect if each agent's effects were independent of each other. Here's a fictitious example of synergy to illustrate my point: Ingredient A causes a 10% improvement and ingredient B causes a 15% percent improvement whereas A+B combo causes a 60% improvement (as opposed to the expected 25% improvement).
According to Sederma, the synergy between palmitoyl oligopeptide and palmitoyl tetrapeptide-7 is dramatic. They reported a tissue culture study where Matrixyl 3000 increased the synthesis of skin matrix roughly 2.5-3.5 times. In particular, the synthesis of collagen type I increased by 258%, fibronectin - by 164% and hyaluronic acid - by 179%.
Sederma also reported a small human study involving two groups of 24 volunteers where Matrixyl 3000 performed considerably better than placebo and somewhat better than "classic" Matrixyl, including the following beneficial effects after two month of daily application *:
Reduction in main wrinkle depth (-15%) and volume (-18%)
Reduction in roughness (-14%)
Reduction in complexity (-16%), "lifting" parameter
Decrease in the area occupied by deep wrinkles (>200 microns) (-44%), -37% decrease in density
Increase in skin tone (+15%) 
Based on the data reported by Sedema corporation, Matrixyl 3000 appear to produce maximum effect at the concentration around 10-15 ppm (combined for both peptides). However, the data is limited and uncorroborated by other sources and valid only for tissue culture. Therefore, the question about optimal strength of Matrixyl 3000 in skin care formulas remains open. The concentration in the formulas used in Sedema's human study was 3%. In its literature, Sedema recommends the range of concentrations from 3% to 8%. Notably, this percentage is calculated based on the Sedema's proprietary stock solution of Matrixyl 3000 (of undisclosed strength) rather than pure peptides.
   
15.SNAP-8(Acetyl octapeptide-8)
Argireline is a hexapeptide, which contains six amino acids in one chain, while Snap-8 is an octapeptide, which contains eight amino acids in one chain. Both peptides have fairly equal anti-wrinkle powers and both can relax facial tensions easily.
Snap-8 is most commonly found as an active ingredient in eye serums and anti-wrinkle creams that focus on the wrinkles and fine lines on the forehead. Snap-8 effectively reduces wrinkle depth around the eyes and on the forehead by relaxing the muscles and vesicles in and around these areas. It is considered as a safer and cheaper alternative to Botox, which can cause several side effects. Snap-8 has no established side effects at all.
  
16.Serilesine (Hexapeptide-10)
SERILESINE® is a hexapeptide that promotes cell adhesion, growth and migration, regenerating the basal lamina.
Serilesine® can be incorporated in cosmetic formulations such as emulsions, gels, and serums where restructuring and refirming of skin is desired.
- SERILESINE® improves cell adhesion by enhancing synthesis of Laminin-5.
- Adhesion of cells to the basement membrane and among themselves provides firmness to the skin.
- Increased contact between skin cells ensures correct nourishment and health.
- Increased skin compactness, elasticity and smoothness.
  
17.Palmitoryl Tetrapeptide-3 (Rigin, or Pal-GQPR)
This peptide contains matrikines (Pal-GHK and Pal-GQPR), which act as messengers and activate certain genes to renew and repair the skin. They activate the neo-synthesis of extracellular matrix macromolecule to minimize wrinkles and fine lines, improve elasticity and tone and face lift effect.
This peptide is used in anti-aging skin care products as it improves skin elasticity and minimizes fine-lines and wrinkles. It is especially helpful for dry or sun-damaged skin.This peptide is used in anti-aging skin care products as it improves skin elasticity and minimizes fine-lines and wrinkles. It is especially helpful for dry or sun-damaged skin.
Palmitoyl Tetrapeptide-3(Pal-GQPR) improves firmness and elasticity and decreases inflammation.Firming up the tissues around the eye helps to decrease puffiness, and decreasing inflammation tends to reduce the redness and soreness that often accompany other unwanted disruptions of the health of these tissues.